Pathology · single question

The patient is most likely suffering from:

Cushing's syndrome
Addison's disease (primary adrenal insufficiency)
Crohn's disease
Hyperthyroidism

Show answer and explanation

Correct answer: B. Addison's disease (primary adrenal insufficiency)

Addison's disease Primary adrenal insufficiency produces low cortisol and aldosterone. The classic tetrad is: fatigue/lethargy, weight loss/anorexia, hypotension, and hyperpigmentation (increased ACTH stimulates MSH and melanocytes). Oral mucosal pigmentation on the buccal mucosa or gingiva is a diagnostic clue.

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