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Pathology · single question

The MOST common sites for intraoral squamous cell carcinoma (SCC) include all of the following EXCEPT:

  1. Lateral border of the tongue
  2. Lower lip (vermilion border)
  3. Floor of the mouth
  4. Buccal mucosa
Show answer and explanation

Correct answer: D. Buccal mucosa

  • A. The lateral border of the tongue is the #1 most common intraoral SCC site.
  • B. The lower lip (vermilion border) is a high-risk site for SCC, particularly due to UV exposure.
  • C. The floor of the mouth is the second most common site — it is a high-risk area.
  • D. Correct. While buccal mucosa SCC does occur, it is NOT one of the most common sites in Western populations. The most common intraoral SCC sites are: (1) lateral border/ventral surface of the tongue, (2) floor of the mouth, (3) lower lip (vermilion), (4) soft palate. Buccal mucosa SCC is more common in populations with betel nut use.

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