Tetracycline can cause intrinsic tooth discoloration if administered from the second trimester in utero up to approximately what age?

Tetracycline binds calcium and incorporates into calcifying teeth, staining both dentitions. It is contraindicated in pregnancy (from about the 4th month) and in children up to about 8 years, when the crowns of most permanent teeth are still forming.Other options: Stopping at 2 or 5 years would leave anterior permanent crowns still at risk; by about age 8 those crowns are largely formed.Key exam takeaway: Avoid tetracyclines in pregnancy and under age 8 to prevent permanent intrinsic staining.