Micro & Immunology · single question
Systemic lupus erythematosus is mediated primarily by which type of hypersensitivity reaction?
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Correct answer: C. Type III
- A. Type I is IgE-mediated immediate hypersensitivity (anaphylaxis, allergic rhinitis).
- B. Type II is antibody-mediated cytotoxicity against cell-surface antigens (e.g., autoimmune hemolytic anemia).
- C. Correct. SLE is principally a Type III immune-complex disease: antigen-antibody complexes deposit in tissues (glomeruli, vessels) and activate complement.
- D. Type IV is delayed, T-cell-mediated (contact dermatitis, TB skin test).
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