Pathology · single question

'Shingles' (a painful, unilateral, dermatomal vesicular rash) is caused by reactivation of which virus?

  1. Varicella-zoster virus (VZV)
  2. Herpes simplex virus type 1
  3. Epstein-Barr virus
  4. Cytomegalovirus
Show answer and explanation

Correct answer: A. Varicella-zoster virus (VZV)

Shingles (herpes zoster) results from reactivation of latent varicella-zoster virus (the same virus causing chickenpox/varicella in primary infection), which has remained dormant in dorsal root or cranial nerve ganglia, and reactivates along a single dermatome, often during times of immunosuppression or aging.

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