Pathology · single question

For the same patient with erythema migrans (geographic tongue), if a biopsy were clinically indicated, which type would be most appropriate?

  1. Immunofluorescence biopsy
  2. Brush (cytology) biopsy
  3. Incisional biopsy
  4. Excisional biopsy
Show answer and explanation

Correct answer: C. Incisional biopsy

In the rare situation where a biopsy is needed for erythema migrans — such as when the diagnosis is uncertain, the lesion is persistent, or there is concern for dysplasia — an INCISIONAL biopsy (removing a representative tissue sample for histopathology) would be the appropriate technique. An excisional biopsy is reserved for small, well-defined lesions where complete removal is both diagnostic and therapeutic. An immunofluorescence biopsy is used for autoimmune vesiculobullous diseases (pemphigoid, pemphigus) — not for geographic tongue. Brush biopsy (cytology) is a cancer screening tool. Important: geographic tongue has a classic clinical presentation and biopsy is generally NOT necessary. This question tests biopsy type selection when a larger, non-resectable lesion requires tissue diagnosis — incisional biopsy is correct.

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