Regarding the interaction between antibiotics and estradiol-containing oral contraceptive pills (OCPs), which statement is FALSE?

Current evidence does not support the belief that routine antibiotics (such as amoxicillin, tetracycline, or metronidazole) reliably reduce the effectiveness of estradiol-containing oral contraceptives. This was a historical concern based on proposed enterohepatic recirculation mechanisms, but controlled studies have not demonstrated a clinically significant reduction in OCP efficacy with non-enzyme-inducing antibiotics. Only enzyme-inducing drugs — primarily rifampin (rifampicin) and certain anticonvulsants — significantly lower estrogen levels and reduce OCP efficacy. Therefore, the statement that most antibiotics hinder OCP effectiveness is FALSE.