Pediatric Dentistry · single question
Primary failure of eruption (PFE) is associated with a mutation in which gene?
Show answer and explanation
Correct answer: B. PTH1R
Primary failure of eruption affects at least one posterior tooth and all teeth distal to it. These teeth do not respond to orthodontic forces and may ankylose. The condition is linked to mutations in the PTH1R gene (parathyroid hormone 1 receptor). Family history is common.
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