Pathology · single question

Physiological pigmentation in a child — what does this represent?

  1. Normal finding (melanin pigmentation in gingiva/oral mucosa, common in many ethnicities)
  2. Addison's disease
  3. Peutz-Jeghers syndrome
  4. Melanoma
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Correct answer: A. Normal finding (melanin pigmentation in gingiva/oral mucosa, common in many ethnicities)

  • A. Correct. Physiologic (racial/ethnic) pigmentation is a common, benign, normal finding of melanin deposition in the gingiva/oral mucosa, particularly in individuals with darker skin tones, requiring no treatment.
  • B. Addison's disease would present with more diffuse, progressive pigmentation associated with systemic symptoms (fatigue, hypotension), not an isolated benign childhood finding.
  • C. Peutz-Jeghers syndrome presents with characteristic perioral/labial pigmented macules associated with GI polyposis, a distinct syndromic presentation.
  • D. Melanoma would present as an irregular, evolving, concerning pigmented lesion, not symmetric physiologic pigmentation.

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