Pathology · single question
Pemphigus vulgaris is best classified as which type of lesion?
Show answer and explanation
Correct answer: B. Autoimmune
- A. Developmental lesions arise from disturbances in embryological development; pemphigus vulgaris is acquired, not developmental.
- B. Correct. Pemphigus vulgaris is an autoimmune blistering disease caused by IgG autoantibodies targeting desmoglein 1 and 3 (desmosomal proteins), leading to intraepithelial acantholysis and painful erosions/blisters.
- C. Reactive lesions (e.g., pyogenic granuloma, fibrous hyperplasia) arise in response to irritation or trauma; pemphigus vulgaris has an autoimmune etiology.
- D. Neoplastic lesions involve abnormal cell proliferation; pemphigus vulgaris is not a tumor.