Pathology · single question

A denture wearer with generalized palatal erythema also has a sore at the corner of the mouth. What is the best medication for the fungal lesion?

  1. Topical acyclovir
  2. Oral amoxicillin
  3. Topical hydrocortisone alone
  4. Topical ketoconazole (or nystatin/clotrimazole) cream
Show answer and explanation

Correct answer: D. Topical ketoconazole (or nystatin/clotrimazole) cream

  • A. Acyclovir treats herpes labialis, which occurs on the vermilion rather than bilaterally at the commissures.
  • B. A systemic antibacterial does not treat a fungal lesion.
  • C. A corticosteroid alone would worsen an untreated fungal infection.
  • D. Correct. Angular cheilitis in a denture wearer is usually Candida, often with a staphylococcal component. A topical azole antifungal treats it, and the underlying denture stomatitis and vertical dimension must also be addressed.

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