Pediatric patient, 7 years old, with bilateral jaw expansion. Histology shows giant cells. What is the diagnosis?

Correct answer: C. Cherubism

• A. OKC is typically unilocular/multilocular radiolucent lesion without giant cells on histology and is not characteristically bilateral.
• B. Hyperparathyroidism causes a 'brown tumor' with giant cells, but it is a systemic endocrine disorder with lab abnormalities (elevated PTH/calcium), not a primary bilateral pediatric jaw condition presenting this way.
• C. Correct. Cherubism is a hereditary fibro-osseous condition presenting in young children with bilateral, painless jaw (especially mandibular) expansion; histology shows multinucleated giant cells in a fibrous stroma.
• D. Ameloblastoma is usually unilateral, more common in adults, and shows odontogenic epithelial islands histologically, not giant cells.