Physiology & Biochemistry · single question

Multiple sclerosis primarily involves which cells, and what is its mechanism?

  1. Autoimmune destruction of oligodendrocytes (CNS myelin)
  2. Autoimmune destruction of Schwann cells (PNS myelin)
  3. Degeneration of dopaminergic neurons
  4. Deposition of amyloid plaques
Show answer and explanation

Correct answer: A. Autoimmune destruction of oligodendrocytes (CNS myelin)

  • A. Correct. MS is an autoimmune demyelinating disease of the CNS targeting oligodendrocyte-derived myelin.
  • B. Schwann cells myelinate the PNS; they are affected in Guillain-Barré, not MS.
  • C. Dopaminergic neuron loss describes Parkinson disease.
  • D. Amyloid plaques are a feature of Alzheimer disease.

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