Physiology & Biochemistry · single question

How is the majority of CO2 transported from tissues back to the lungs in blood?

  1. As carbon monoxide
  2. Dissolved in plasma only
  3. As bicarbonate (via carbonic anhydrase)
  4. Bound to hemoglobin only
Show answer and explanation

Correct answer: C. As bicarbonate (via carbonic anhydrase)

  • A. Incorrect – CO is a toxic gas, not a CO2 transport form.
  • B. Incorrect – only ~7–10% travels dissolved.
  • C. Correct – ~70% of CO2 is carried as HCO3− after carbonic anhydrase in RBCs converts CO2 + H2O → H2CO3 → HCO3−.
  • D. Incorrect – carbaminohemoglobin carries ~20–23%, not the majority.

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