Physiology & Biochemistry · single question

Most common chromosomal abnormality (trisomy / Down syndrome)?

  1. Chromosome 21
  2. Chromosome 12
  3. Chromosome 23
  4. Chromosome 8
Show answer and explanation

Correct answer: A. Chromosome 21

  • A. Correct. Trisomy 21 (Down syndrome) is the most common viable autosomal trisomy.
  • B. Incorrect. Trisomy 12 is not a common viable trisomy.
  • C. Incorrect. There is no 'chromosome 23'; humans have 22 autosome pairs plus the sex chromosomes.
  • D. Incorrect. Trisomy 8 mosaicism exists but is far less common than trisomy 21.

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