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Pathology · single question

Minor salivary gland (lip) biopsy for suspected Sjogren's syndrome. Expected histological finding?

  1. Fat cells replacing acinar tissue
  2. Non-caseating granulomas
  3. Plasma cell infiltrate with Russell bodies
  4. Focal lymphocytic sialadenitis (periductal lymphocytic infiltrates)
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Correct answer: D. Focal lymphocytic sialadenitis (periductal lymphocytic infiltrates)

Lip biopsy for Sjogren's: FOCAL LYMPHOCYTIC SIALADENITIS — periductal aggregates of ≥50 lymphocytes (foci) per 4mm2 glandular tissue. Focus score ≥1 is diagnostic. Granulomatous inflammation = sarcoidosis. Fat replacement = chronic sialadenitis/aging.

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