Pharmacology · single question
Methotrexate is an antagonist of which vitamin (folinic-acid 'rescue' is given to counter it)?
Show answer and explanation
Correct answer: A. Vitamin B9 (folic acid)
- A. Correct – methotrexate inhibits dihydrofolate reductase (a folic-acid/B9 antagonist); leucovorin (folinic acid) is used as rescue.
- B. Incorrect – not the target of methotrexate.
- C. Incorrect – unrelated to folate metabolism here.
- D. Incorrect – unrelated to methotrexate's mechanism.