Pharmacology · single question
A patient taking bisphosphonates for osteoporosis — what is the mechanism of action and which cells do these drugs affect?
Show answer and explanation
Correct answer: A. Inhibit osteoclast activity and induce osteoclast apoptosis
- A. Correct. Bisphosphonates (e.g., zoledronic acid, alendronate, risedronate) are incorporated into bone and inhibit osteoclast activity, reducing bone resorption. They also induce osteoclast apoptosis. This is why MRONJ occurs — osteoclast suppression impairs normal bone remodeling and healing.
- B. Vitamin D receptor activation is a different mechanism related to calcium metabolism.
- C. Bisphosphonates do not stimulate osteoblasts — they target osteoclasts.
- D. Bisphosphonates do not block calcium channels.