Oral Surgery · single question

Medication-related osteonecrosis of the jaw (MRONJ) can be caused by which class of medications, beyond bisphosphonates?

  1. Anti-angiogenic agents
  2. Antihypertensive medications
  3. Antibiotics
  4. Antihistamines
Show answer and explanation

Correct answer: A. Anti-angiogenic agents

Anti-angiogenic medications (such as bevacizumab and certain tyrosine kinase inhibitors used in cancer treatment) are recognized, in addition to bisphosphonates and denosumab (a RANKL inhibitor), as a cause of medication-related osteonecrosis of the jaw, given their effects on bone vascularity and remodeling.

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