Pathology · single question
Langerhans cell histiocytosis (LCH) is most likely to be radiographically mistaken for which condition?
Show answer and explanation
Correct answer: C. Multiple myeloma
- A. Pindborg tumor (CEOT) contains radiopaque 'driven snow' calcifications — quite different from LCH.
- B. Ameloblastoma has a characteristic multilocular 'soap bubble' or 'honeycomb' pattern — different from LCH.
- C. Correct. LCH classically presents as multiple 'punched-out' lytic bone lesions radiographically identical to those of multiple myeloma. Both show floating teeth, endosteal scalloping, and skull vault lesions. Multiple myeloma is the most important radiographic mimic.
- D. OKC appears as a unilocular or multilocular radiolucency with scalloped margins — distinctive from LCH.