Pathology · single question
In Mucous Membrane Pemphigoid, which cellular structure is specifically affected?
Show answer and explanation
Correct answer: A. Hemidesmosomes
MMP involves autoantibodies against hemidesmosomes (BP180, BP230), causing subepithelial blistering — separation below the epithelium.
- A. ✅ CORRECT – MMP targets hemidesmosomes (basement membrane zone); subepithelial split.
- B. ❌ Gap junctions facilitate cell communication; not targeted in MMP.
- C. ❌ Tight junctions maintain the epithelial barrier; not targeted in MMP.
- D. ❌ Desmosomes are targeted in Pemphigus Vulgaris (intraepithelial blistering).