Pathology · single question

In cherubism, the radiolucent, multilocular ('soap bubble') appearance on radiographs is produced primarily by the activity of which cell type?

  1. Odontoblasts
  2. Odontoclasts
  3. Osteoclasts (within a fibro-osseous lesion containing numerous multinucleated giant cells)
  4. Osteoblasts
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Correct answer: C. Osteoclasts (within a fibro-osseous lesion containing numerous multinucleated giant cells)

Cherubism is a fibro-osseous lesion of the jaws driven by numerous osteoclast-like multinucleated giant cells, which resorb bone and create the classic bilateral, multilocular radiolucent ('soap bubble') pattern, typically in the posterior mandible of children, often regressing after puberty.

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