Pathology · single question
Civatte bodies are seen in which condition?
Show answer and explanation
Correct answer: A. Oral lichen planus
- A. Civatte bodies (colloid bodies, hyaline bodies) are eosinophilic, homogeneous, rounded structures representing APOPTOTIC KERATINOCYTES at the epithelial-connective tissue junction in LICHEN PLANUS. They are the histopathological hallmark of lichen planus and result from basal cell degeneration (liquefactive/hydropic degeneration).
- B. Erythema multiforme shows satellite cell necrosis — not Civatte bodies. Civatte bodies are specific to lichen planus.
- C. MMP shows subepithelial blistering with IgG and complement at the basement membrane zone — NOT Civatte bodies.
- D. Pemphigus vulgaris shows intraepithelial acantholytic cells (Tzanck cells) and IgG antibody binding to desmoglein — NOT Civatte bodies.