Physiology & Biochemistry · single question

How is most carbon dioxide transported in the blood back to the lungs for elimination?

  1. Dissolved as free CO2 gas in plasma
  2. Bound to hemoglobin as carbaminohemoglobin
  3. As bicarbonate ion (HCO3-), formed via the carbonic anhydrase reaction inside red blood cells
  4. As carbonic anhydride gas
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Correct answer: C. As bicarbonate ion (HCO3-), formed via the carbonic anhydrase reaction inside red blood cells

About 70% of CO2 is carried as bicarbonate (CO2 + H2O ⇌ H2CO3 ⇌ H+ + HCO3-, catalyzed by carbonic anhydrase in RBCs), about 20-23% is bound to hemoglobin as carbaminohemoglobin, and only about 7% is dissolved as free CO2 in plasma. ('Carbonic anhydride' is not a real transport form — the enzyme is carbonic anhydrase.)

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