Pathology · single question

Gorlin syndrome (nevoid basal cell carcinoma syndrome) is characterized by all of the following EXCEPT:

  1. Multiple odontogenic keratocysts (OKC)
  2. Bifid ribs
  3. Multiple basal cell carcinomas
  4. Calcified crista galli (falx cerebri is the correct structure)
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Correct answer: D. Calcified crista galli (falx cerebri is the correct structure)

  • A. Multiple odontogenic keratocysts (OKC) — often the first manifestation — are a defining feature.
  • B. Bifid ribs are a cardinal feature of Gorlin syndrome.
  • C. Multiple basal cell carcinomas (BCCs) develop early in life — characteristic of Gorlin syndrome.
  • D. Correct answer as the exception. Gorlin syndrome features: multiple OKCs, multiple basal cell carcinomas, bifid ribs, and CALCIFIED FALX CEREBRI (not crista galli). The calcified falx cerebri is a classic radiographic finding. Know the correct anatomical term.

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