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Pathology · single question

A patient with Gorlin-Goltz syndrome (Basal Cell Nevus Syndrome) is most likely to have which jaw lesion?

  1. Dentigerous cyst
  2. Ameloblastoma
  3. Central giant cell granuloma
  4. Odontogenic keratocyst (OKC)
Show answer and explanation

Correct answer: D. Odontogenic keratocyst (OKC)

Gorlin-Goltz = PTCH1 gene mutation. Multiple OKCs (jaw), multiple basal cell carcinomas, calcified falx cerebri, bifid ribs. Multiple OKCs in 1st-2nd decade = hallmark finding.

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