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Pathology · single question

Each of the following is TRUE about HPV (human papillomavirus) EXCEPT:

  1. HPV 16 and 18 are malignant (high-risk) strains
  2. It is associated with oral squamous cell carcinoma
  3. The HPV vaccine protects against strains that cause cancer
  4. It infects basal epithelial cells
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Correct answer: B. It is associated with oral squamous cell carcinoma

  • A. Incorrect — HPV 16 and 18 ARE high-risk oncogenic strains. They cause most HPV-related head and neck, cervical, and oropharyngeal cancers.
  • B. Per the source, 'associated with oral squamous cell carcinoma' was selected as the exception (CORRECT ANSWER). While HPV is strongly linked to OROPHARYNGEAL SCC (base of tongue, tonsil), its association with conventional ORAL SCC (lip, tongue, floor of mouth) is weaker. The distinction between oral and oropharyngeal SCC may be the intended nuance.
  • C. Incorrect — the HPV vaccine (Gardasil 9) DOES protect against cancer-causing strains including HPV 16, 18, and others.
  • D. Incorrect — HPV DOES infect basal epithelial cells. HPV requires actively dividing cells and gains access through microabrasions in the epithelium.

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