Pharmacology · patient case question
Each of the following is a recognized adverse effect of terazosin EXCEPT one. Which is the exception?
Patient case: Antihypertensive Review & Gingival Enlargement
demo: 60-year-old male
chief: “My gums have been growing over my front teeth.”
history: Hypertension, benign prostatic hyperplasia, angina.
meds: Nifedipine, prazosin, terazosin, atenolol
findings: Generalized fibrotic enlargement of the interdental papillae, most marked in the anterior maxilla. Plaque index moderate. No bone loss on bitewings.
Show answer and explanation
Correct answer: D. Bleeding
- A. Nasal congestion follows from loss of alpha-mediated vasoconstriction in the nasal mucosa.
- B. Dizziness is common with alpha-1 blockade, particularly on standing.
- C. Orthostatic hypotension, especially the first-dose phenomenon, is characteristic of this class.
- D. Correct — this is the exception. Alpha-1 blockers do not affect platelet function or the coagulation cascade, so bleeding is not an expected adverse effect.