Pharmacology · single question
Which antibiotic is NOT safe in pregnancy?
Show answer and explanation
Correct answer: A. Tetracycline
Tetracycline (A) is contraindicated in pregnancy (FDA Category D). It crosses the placenta and deposits in developing bone and teeth, causing permanent intrinsic yellow-brown-gray discoloration of deciduous teeth (and permanent teeth if taken later in pregnancy). It also inhibits fetal bone growth.
• Azithromycin (B) is FDA Category B — generally considered safe in pregnancy when benefit outweighs risk.
• Erythromycin (C) is FDA Category B — historically the antibiotic of choice for penicillin-allergic pregnant patients (though estolate salt is avoided).
• Clindamycin (D) is FDA Category B — safe option for dental infections.
• Safe antibiotics in pregnancy: penicillins, cephalosporins, azithromycin, clindamycin. Avoid: tetracyclines, fluoroquinolones, metronidazole (1st trimester).
• Azithromycin (B) is FDA Category B — generally considered safe in pregnancy when benefit outweighs risk.
• Erythromycin (C) is FDA Category B — historically the antibiotic of choice for penicillin-allergic pregnant patients (though estolate salt is avoided).
• Clindamycin (D) is FDA Category B — safe option for dental infections.
• Safe antibiotics in pregnancy: penicillins, cephalosporins, azithromycin, clindamycin. Avoid: tetracyclines, fluoroquinolones, metronidazole (1st trimester).