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Pathology · single question

Civatte bodies (hyaline/colloid bodies) are a histologic hallmark of which condition, and what is its first-line treatment?

  1. Pemphigus vulgaris — systemic steroids
  2. Oral lichen planus — clobetasol propionate
  3. Erythema multiforme — acyclovir
  4. Mucous membrane pemphigoid — dapsone
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Correct answer: B. Oral lichen planus — clobetasol propionate

Civatte bodies (colloid bodies) = eosinophilic globular remnants of apoptotic basal keratinocytes = pathognomonic for oral lichen planus. First-line treatment: clobetasol propionate 0.05% (potent topical steroid). Source confirms: 'civatte bodies = clobetasol.'
  • A. Pemphigus vulgaris shows suprabasilar acantholysis and Tzanck cells — NOT Civatte bodies.
  • B. CORRECT. Civatte bodies = oral lichen planus. Treatment = clobetasol (potent topical steroid).
  • C. Erythema multiforme shows satellite cell necrosis — not Civatte bodies. Treated with antivirals if HSV-triggered.
  • D. MMP shows subepithelial clefting — not Civatte bodies. May need dapsone or immunosuppressives.

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