Pathology · single question

Cherubism is classified as which type of lesion?

  1. Reactive (inflammatory) lesion
  2. Developmental (hereditary/genetic) lesion
  3. Neoplastic (true tumor) lesion
  4. Infectious lesion
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Correct answer: B. Developmental (hereditary/genetic) lesion

Cherubism is classified as a developmental/hereditary lesion — specifically an autosomal dominant fibro-osseous condition caused by mutations in SH3BP2. It is not reactive (not triggered by inflammation/infection) and not a true neoplasm. It involves bilateral symmetric replacement of jaw bone by fibrous tissue containing giant cells. It appears in early childhood and often regresses spontaneously after puberty. Classification: developmental/genetic.

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