Pharmacology · single question

Carbamazepine works by:

  1. Potassium channel blockade
  2. Voltage-gated sodium channel blockade
  3. GABA receptor agonism
  4. NMDA receptor antagonism
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Correct answer: B. Voltage-gated sodium channel blockade

Carbamazepine stabilizes voltage-gated NaÔü║ channels in the inactivated state, reducing repetitive neuronal firing. It is first-line for trigeminal neuralgia and focal seizures. Phenytoin has the same mechanism.

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