Pharmacology · single question

Carbamazepine is used for trigeminal neuralgia. Its mechanism of action is:

  1. GABA receptor agonist
  2. Potassium channel blocker
  3. Sodium channel blocker
  4. Calcium channel (T-type) blocker
Show answer and explanation

Correct answer: C. Sodium channel blocker

  • A. GABA receptor agonism describes benzodiazepines and barbiturates, not carbamazepine.
  • B. Potassium channel blockers are used in a different pharmacological context (e.g., some cardiac arrhythmias); not the mechanism of carbamazepine.
  • C. Correct. Carbamazepine blocks voltage-gated sodium channels, stabilizing neuronal membranes and reducing repetitive firing. This is the basis for its anticonvulsant and analgesic effects in trigeminal neuralgia.
  • D. T-type calcium channel blockers (e.g., ethosuximide) are used for absence seizures — not carbamazepine's mechanism.

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