Pathology · single question

All of the following could be in the differential diagnosis for a rounded reddish nodule in the interdental papilla between the canine and lateral incisor EXCEPT:

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  1. Pleomorphic adenoma
  2. Fibroma
  3. Pyogenic granuloma
  4. Papilloma
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Correct answer: A. Pleomorphic adenoma

Fibroma, pyogenic granuloma, and papilloma are all common, well-recognized reactive/benign soft tissue lesions that frequently present as gingival/interdental papillary nodules from local irritation or HPV infection. Pleomorphic adenoma is a salivary gland tumor that arises from major or minor salivary gland tissue (e.g., palate, lip, buccal mucosa) — it is not a typical differential for an interdental papilla lesion, which lacks significant salivary gland tissue, making it the exception.

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