Start practicing

Medical Emergencies · single question

All of the following are characteristics of Factor V Leiden (thrombophilia) EXCEPT:

  1. Women taking oral contraceptives have little risk of thrombosis
  2. Autosomal dominant inheritance
  3. Resistance to activated protein C
  4. Increased risk of venous thromboembolism
Show answer and explanation

Correct answer: A. Women taking oral contraceptives have little risk of thrombosis

  • A. CORRECT (EXCEPTION) — This is FALSE. Women with Factor V Leiden who take oral contraceptives (estrogen-containing) have a MARKEDLY INCREASED risk of thrombosis — the combination is synergistic and dramatically increases VTE risk (up to 35-fold compared to non-carriers not on OCP).
  • B. INCORRECT — Factor V Leiden is autosomal dominant with variable penetrance; one copy of the mutation increases thrombosis risk.
  • C. INCORRECT — Factor V Leiden creates a mutated Factor V that is resistant to degradation by activated protein C (APC resistance), which is the core mechanism of thrombophilia.
  • D. INCORRECT — Factor V Leiden is the most common inherited thrombophilia and significantly increases risk of DVT and pulmonary embolism.

Practice Medical Emergencies questions Medical Emergencies study notes

More Medical Emergencies practice questions