Pathology · single question

All of the following are associated with Paget's disease of bone EXCEPT:

  1. High dietary glucose intake
  2. Hypercementosis of teeth
  3. Characteristic 'cotton wool' radiographic appearance of affected bone
  4. Elevated serum alkaline phosphatase
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Correct answer: A. High dietary glucose intake

Paget's disease of bone results from abnormal osteoclast activity and disorganized bone remodeling (with proposed genetic and possibly viral contributing factors), producing hypercementosis, a 'cotton wool' radiographic appearance, and elevated alkaline phosphatase (reflecting high bone turnover) — high dietary glucose intake is not a recognized risk factor or association for this condition.

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