Anesthesia · single question

A study comparing articaine to lidocaine for dental anesthesia reports an RR of 3.1, 95% CI of 3.4-4.7, and p-value < 0.001. However, note that the confidence interval (3.4-4.7) does NOT include the point estimate (RR 3.1), which indicates a data error in the original question. Assuming the CI correctly brackets the RR and does not cross 1.0, what does this study tell us about articaine's efficacy?

  1. Articaine is safer to use than lidocaine
  2. Lidocaine is more effective than articaine
  3. Articaine is more effective than lidocaine, and the result is statistically significant
  4. Articaine and lidocaine have equal efficacy
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Correct answer: C. Articaine is more effective than lidocaine, and the result is statistically significant

Interpretation of this statistical question: An RR > 1.0 indicates that the exposed group (articaine) has a higher rate of the outcome (anesthetic success) than the comparison group (lidocaine), meaning articaine is MORE effective. A p-value < 0.001 confirms the result is statistically significant. A 95% confidence interval that does not include 1.0 (the null value for RR) also indicates statistical significance. Note: the question has a data error — the stated CI (3.4-4.7) does not bracket the point estimate (RR 3.1); a corrected CI might be 2.4-4.7. Despite this, the interpretation principle remains: RR > 1, CI not crossing 1, p < 0.05 all indicate a statistically significant positive association favoring articaine.

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