Anesthesia · single question
A study comparing articaine to lidocaine for dental anesthesia reports an RR of 3.1, 95% CI of 3.4-4.7, and p-value < 0.001. However, note that the confidence interval (3.4-4.7) does NOT include the point estimate (RR 3.1), which indicates a data error in the original question. Assuming the CI correctly brackets the RR and does not cross 1.0, what does this study tell us about articaine's efficacy?
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Correct answer: C. Articaine is more effective than lidocaine, and the result is statistically significant
Interpretation of this statistical question: An RR > 1.0 indicates that the exposed group (articaine) has a higher rate of the outcome (anesthetic success) than the comparison group (lidocaine), meaning articaine is MORE effective. A p-value < 0.001 confirms the result is statistically significant. A 95% confidence interval that does not include 1.0 (the null value for RR) also indicates statistical significance. Note: the question has a data error — the stated CI (3.4-4.7) does not bracket the point estimate (RR 3.1); a corrected CI might be 2.4-4.7. Despite this, the interpretation principle remains: RR > 1, CI not crossing 1, p < 0.05 all indicate a statistically significant positive association favoring articaine.