A severe allergic reaction to antibiotics can cause which of the following life-threatening conditions?

Stevens-Johnson syndrome (SJS) is a severe, life-threatening mucocutaneous hypersensitivity reaction most commonly triggered by medications, including antibiotics (sulfonamides, penicillins, cephalosporins). It involves widespread epidermal detachment and erosion of mucous membranes. SJS/toxic epidermal necrolysis (TEN) represents a spectrum of the same disease, with TEN affecting >30% of body surface area. Nausea and vomiting are common but mild antibiotic side effects. Thrombocytopenia can occur but is not the classic severe allergic manifestation. SJS requires hospitalization, often in a burn unit.