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Pharmacology · single question

What is the mechanism of action of diuretics such as hydrochlorothiazide?

  1. Block calcium channels in the heart
  2. Inhibit ACE converting angiotensin I to II
  3. Block reabsorption of sodium in the renal tubules
  4. Stimulate beta-2 receptors in the kidneys
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Correct answer: C. Block reabsorption of sodium in the renal tubules

  • A. Calcium channel blockade is the mechanism of CCBs (e.g., amlodipine), not diuretics.
  • B. ACE inhibition is the mechanism of ACE inhibitors like lisinopril, not diuretics.
  • C. Correct. Thiazide diuretics (like hydrochlorothiazide) work primarily by inhibiting sodium reabsorption in the distal convoluted tubule, increasing urine output. Loop diuretics (furosemide) act in the loop of Henle.
  • D. Beta-2 receptor stimulation is the mechanism of bronchodilators like albuterol.

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