Pathology · single question

A pregnant woman has a pedunculated, red, highly vascular gingival mass that bleeds easily. Histology shows lobular capillary proliferation. What is the most likely diagnosis?

  1. Pyogenic granuloma (pregnancy tumor)
  2. Kaposi sarcoma
  3. Peripheral giant cell granuloma
  4. Peripheral ossifying fibroma
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Correct answer: A. Pyogenic granuloma (pregnancy tumor)

Pyogenic granuloma (pregnancy tumor) is a benign, highly vascular gingival lesion during pregnancy driven by elevated progesterone/estrogen. Red, pedunculated, easily bleeding. Histology: lobular capillary proliferation. Treat conservatively after delivery.
  • A. CORRECT. Pyogenic granuloma = pregnancy tumor. Hormonal exaggeration of response to local irritants. Questions #156 and #191.
  • B. Kaposi sarcoma is associated with HIV/AIDS — multiple purple/red lesions, not pregnancy-specific.
  • C. Peripheral giant cell granuloma is dark-red/blue-purple, typically near edentulous ridges, contains multinucleated giant cells histologically.
  • D. Peripheral ossifying fibroma is firmer, pinker, and often calcified — arises from PDL.

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