Pathology · single question

Same HPV case — what was the ORIGIN of the lesion?

  1. Bacterial
  2. Viral
  3. Traumatic
  4. Fungal
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Correct answer: B. Viral

  • A. Bacterial oral lesions do not produce papillary exophytic growths with koilocytes.
  • B. Oral papilloma with koilocytes on histopathology is definitively VIRAL in origin — caused by Human Papillomavirus (HPV). The patient history (smoked, worked a lot, lesion grew over 2 months, eventually bit into it) combined with papillary morphology and koilocytes confirms HPV etiology.
  • C. Traumatic lesions include fibromas and traumatic ulcers — they would NOT show koilocytes on histopathology.
  • D. Fungal oral lesions (candidiasis) present as white plaques or red areas — not papillary growths with koilocytes.

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