Pathology · single question

A patient's lab shows elevated SSA (anti-Ro) antibodies. Most consistent diagnosis?

  1. Sjogren's syndrome
  2. Scleroderma
  3. Rheumatoid arthritis
  4. Systemic lupus erythematosus
Show answer and explanation

Correct answer: A. Sjogren's syndrome

Anti-SSA (Ro) antibodies are most strongly associated with PRIMARY SJOGREN'S syndrome (also seen in SLE). In Sjogren's, both SSA and SSB (anti-La) antibodies are characteristic. RA = anti-CCP and RF. Scleroderma = anti-Scl-70 and anti-centromere.

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