Pathology · single question

A patient with HIV and a CD4 count of 120 cells/mm³ presents with a blue-purple vascular lesion on the hard palate. What is the most likely diagnosis?

  1. Pleomorphic adenoma
  2. Kaposi sarcoma
  3. Mucocele
  4. Pyogenic granuloma
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Correct answer: B. Kaposi sarcoma

Kaposi sarcoma (caused by HHV-8) is an AIDS-defining vascular neoplasm that classically presents as a blue, purple, or red macule/nodule on the hard palate in patients with advanced HIV disease (CD4 <200 is the AIDS-defining threshold). A pleomorphic adenoma is a firm, painless salivary gland tumor without this color, and a mucocele/pyogenic granuloma would not match this immunosuppressed presentation pattern.

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