A patient of African descent with a history of splenectomy presents with oral findings including delayed wound healing and bone pain. What is the most likely diagnosis?

Sickle cell anemia is an autosomal recessive hemoglobin disorder most prevalent in individuals of African descent. Splenectomy is commonly performed in sickle cell disease due to functional asplenia or splenic sequestration crises. Oral manifestations include: osteomyelitis and osteonecrosis of the jaw (due to vascular occlusion), pallor of oral mucosa, delayed eruption, and hypercementosis. Bone pain (vaso-occlusive crises) is characteristic. Behcet's disease causes recurrent oral ulcers but is more common in Middle Eastern/Asian populations and is not associated with splenectomy. Thalassemia presents with characteristic facial changes (bossing). Iron deficiency presents with pallor and glossitis.