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Pharmacology · single question

A patient with Factor V Leiden is taking apixaban. What is the mechanism of action of apixaban?

  1. Directly inhibits Factor Xa
  2. Inhibits platelet ADP receptor (P2Y12)
  3. Antagonizes vitamin K
  4. Directly inhibits thrombin (Factor IIa)
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Correct answer: A. Directly inhibits Factor Xa

  • A. Correct. Apixaban (Eliquis) is a DIRECT FACTOR Xa INHIBITOR. Factor Xa converts prothrombin to thrombin. By blocking Factor Xa, apixaban prevents thrombin generation and clot formation.
  • B. Incorrect. P2Y12 inhibition is the MOA of clopidogrel. Apixaban does not affect platelets.
  • C. Incorrect. Vitamin K antagonism is the MOA of warfarin.
  • D. Incorrect. Direct thrombin inhibition is the MOA of dabigatran (Pradaxa).

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