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Pharmacology · single question

A patient who had a total knee replacement 10 years ago and has mitral valve prolapse needs an extraction. Appropriate antibiotic prophylaxis is:

  1. Amoxicillin 2 g one hour before
  2. Clindamycin 600 mg one hour before
  3. No antibiotic prophylaxis is indicated
  4. Azithromycin 500 mg
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Correct answer: C. No antibiotic prophylaxis is indicated

  • A. Amoxicillin prophylaxis is reserved for specific high-risk cardiac conditions, which MVP is not.
  • B. Clindamycin is the penicillin-allergic alternative only when prophylaxis is actually indicated.
  • C. Correct. Mitral valve prolapse is NOT a high-risk cardiac condition, and a well-healed joint replacement years out generally needs no prophylaxis.
  • D. Azithromycin is an alternative only when prophylaxis is indicated.

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