Pharmacology · single question

A patient taking IV zoledronate needs dental extractions. The appropriate management is to:

  1. Refer to an oral/maxillofacial surgeon for evaluation and careful management
  2. Extract immediately in general practice without precautions
  3. Prescribe long-term opioids and observe
  4. Place immediate implants in the sockets
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Correct answer: A. Refer to an oral/maxillofacial surgeon for evaluation and careful management

  • A. Correct. IV bisphosphonates (zoledronate) carry a meaningful MRONJ risk with extractions; referral to an oral surgeon for risk assessment, atraumatic technique, and close follow-up is appropriate.
  • B. Routine immediate extraction without precautions ignores the MRONJ risk.
  • C. Opioids do not address the surgical/MRONJ risk.
  • D. Implant placement is contraindicated/high-risk during active IV bisphosphonate therapy.

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