A patient presents with oral ulcers, and biopsy of the large intestine shows fissured and ulcerated mucosa. What is the most likely diagnosis?

Correct answer: D. Crohn's disease

• A. INCORRECT — Behçet's disease causes recurrent oral ulcers, genital ulcers, and eye involvement but is not a GI inflammatory disease causing bowel fissuring.
• B. INCORRECT — Ulcerative colitis primarily involves the COLON in a continuous pattern without skip lesions; oral manifestations occur but are less characteristic. The fissured, transmural description fits Crohn's better.
• C. INCORRECT — Celiac disease is an autoimmune response to gluten affecting the small intestine (villi flattening), not producing fissured/ulcerated bowel. Oral manifestations include recurrent aphthous stomatitis and enamel defects.
• D. CORRECT — Crohn's disease (regional enteritis) characteristically produces TRANSMURAL, skip lesion, fissured, and ulcerated bowel mucosa, AND has well-documented oral manifestations including cobblestone appearance of oral mucosa, aphthous-like ulcers, lip/tissue tags, and granulomatous oral lesions.