Pathology · single question

A patient who had multiple odontogenic keratocysts (OKCs) five years ago now develops a basal-cell skin lesion. The most likely underlying condition is:

  1. Nevoid basal cell carcinoma syndrome (Gorlin syndrome)
  2. Cutaneous squamous cell carcinoma
  3. Malignant melanoma
  4. Keratoacanthoma
Show answer and explanation

Correct answer: A. Nevoid basal cell carcinoma syndrome (Gorlin syndrome)

  • A. Correct. Multiple OKCs plus basal-cell skin lesions are classic for Gorlin (nevoid basal cell carcinoma) syndrome.
  • B. SCC is not linked to multiple OKCs.
  • C. Melanoma is unrelated to OKCs.
  • D. A solitary keratoacanthoma does not explain the OKC history.

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