Pathology · single question

A patient presents with dark pigmented macules on the tongue. Which is NOT a diagnostic consideration?

  1. Glossitis
  2. Peutz-Jeghers syndrome
  3. Physiologic pigmentation
  4. Addison disease
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Correct answer: A. Glossitis

  • A. Correct. Glossitis is inflammation (a smooth, red/sore tongue), not a cause of discrete dark PIGMENTED macules — so it doesn't belong on the differential for pigmented lesions.
  • B. Peutz-Jeghers syndrome causes mucocutaneous melanotic macules — a valid consideration.
  • C. Physiologic (racial) pigmentation produces benign melanotic areas — a valid consideration.
  • D. Addison disease causes diffuse mucosal hyperpigmentation — a valid consideration.

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